A new study by researchers from Harvard T.H. Chan School of Public Health and colleagues describes the pre-clinical development of a therapeutic that could potentially be used to treat type 2 diabetes, fatty liver disease, and other metabolic diseases. The researchers developed an antibody that improves glucose regulation and reduces fatty liver in obese mice by targeting a hormone in adipose (fat) tissue called aP2 (also known as FABP4).The study was published online December 23, 2015 in Science Translational Medicine.“The importance of this study is two-fold: first, demonstrating the importance of aP2 as a critical hormone in abnormal glucose metabolism, and secondly, showing that aP2 can be effectively targeted to treat diabetes and potentially other immunometabolic diseases,” said Gökhan S. Hotamisligil, J.S. Simmons Professor of Genetics and Metabolism and chair of the Department of Genetics and Complex Diseases and the Sabri Ülker Center at Harvard Chan School.The work is the product of a collaboration on immunometabolism between the biopharmaceutical company UCB and a team of researchers led by Hotamisligil and lead author M. Furkan Burak, a former Hotamisligil lab member and currently a resident in internal medicine at Mount Auburn Hospital, Cambridge, Mass. This partnership successfully twins UCB’s world-class expertise in monoclonal antibody discovery with Hotamisligil’s insight and experience in aP2 biology. Read Full Story
Primoz Roglic retained his lead on compatriot Tadej Pogacar atop the Tour de France standings after stage 18 as British outfit Ineos claimed a one-two finish on Thursday.Bedevilled by problems that saw them withdraw their captain Egan Bernal on Wednesday, team-mate Michal Kwiatkowski won the stage as Richard Carapaz took the King of the Mountains jersey with the pair crossing the finish line three minutes ahead of the elite pack.”I had the best legs ever, the way we rode together with Richard was just incredible,” said Ineos’s Polish rider who is a former world champion. Topics : “When Egan left the race he was very sad but wished us well, and now we have this wonderful day,” he said.”That’s the Tour de France,” he beamed.Giro d’Italia champion Carapaz has been a revelation over the three Alpine stages that culminated with the Ineos-led escape here as the Ecuadorian has relentlessly attacked, picking up climb points to take the polka dot jersey. Beaming with joy Carapaz was drafted into the race at the last minute as Geraint Thomas was farmed out to the Giro, but he fell on stage one in the deluge in Nice and is only finding his full form now.Carapaz and Kwiatkowski were clearly brimming with joy over the fruits of their partnership, which will have brought some relief for Ineos team principal Dave Brailsford, who had to pull out his protégé Bernal to protect him.”Adapting quickly to change is one of the main keys of success,” Brailsford said ahead of the Tour in Nice.”We worked so hard since we changed our objectives,” Kwiatkowski said fighting back tears.In the race for the overall standings only Saturday’s individual time trial presents a chance for the second-placed Pogacar to stage a coup.Roglic leads Pogacar by 57 seconds with Friday’s stage 19 and the culminating run up the Champs-Elysees on Sunday both set to be decided in a mass bunch sprint.Roglic once again looked at ease during the run over three major mountains.”I managed to relax, everything went fine, another good day for us,” Roglic said, as he grows into the role of leader which seemed to weigh on him when he took the lead in the first week.”I’ve been thinking about the time trial, I’ll make the decision how I play it on the day,” he said looking to Saturday’s decider.Stage 17 solo winner Miguel Angel Lopez of Colombia is still third 1min 27sec off the lead but is less of a time-trailer than his rivals.Often unlucky Australian Richie Porte survived a puncture atop the final plateau section where the peloton had to negotiate a gravel surface.Spain’s Mikel Landa rounds out the top five after Briton Adam Yates lost some time over the final climb.
By Dave PanskeOSHKOSH, Wis. (June 13) – T.J. Smith will argue any inference of full moon racing couple with a Friday the 13th after winning his career first Automotive Supply Company IMCA Modified feature at Oshkosh SpeedZone Raceway.Smith grabbed the lead at the start with Jim Rhode Ed Lemay, Eric Arneson, Jeremy Christians and Travis Spaulding close behind. Several early cautions kept the field bunched but Smith was able to maintain to lead through a green flag run from laps four to 10.Christains moved into the runner-up spot on lap six with Mike Wedelstadt and Eddie Muenter moving into the top five by lap seven. With the field right behind for the restart, Smith again set the pace and opened a car length lead over Christians as Muenster, Rhode and Wedelstadt moved up to challenge for second.A final caution on lap 17 set up a three-lap dash, with Smith drawing on his past experience to just run his race and drove off with his first career division feature win. Muenster wrestled the second place finish from Christians on the final lap with point leader Sean Jerovetz making a late-race run to fourth over Wedelstadt and Rhode. Other feature winners were John Heinz in his second straight Total Power Sales IMCA Stock Car feature while Steve Schneider picked up his third Karl Chevrolet Northern SportMod victory on the season.
Share Facebook Twitter Google + LinkedIn Pinterest Twelve young Ohioans have been named recipients of $1,500 college scholarships from the Ohio Farm Bureau Federation Foundation. Supported by the Ohio Farm Bureau Federation, the foundation annually recognizes Ohio students for their academic effort, engagement in their communities and career interests that link agriculture to community service, education or scientific research.Scholarship winners for 2015 are Brooke Anderson of Xenia, Emily Bauman of Otway, Kristen Eisenhauer of Shiloh, Amy Jo Frost of Bloomingburg, Nicki Gordon-Coy of Carrollton, Brianna Gwirtz of Shelby, Rachel Hand of Lewis Center, Ella Grace Jackson of De Graff, Matthew Klopfenstein of Haviland, Abigale Motter of Mansfield, Amanda O’Reily of Middlefield and Lindsay Overmyer of Fremont. Ohio Farm Bureau Foundation Scholar AwardFrost, Motter and Overmyer are recipients of the Ohio Farm Bureau Foundation Scholar Award, which recognizes students for academic effort, community service and career interests that use agriculture to enhance the partnership between farmers and consumers. Frost is a 2009 graduate of Miami Trace High School, 2014 graduate of Ohio State University and is currently pursuing a master’s degree in agricultural and extension education. Motter is a 2015 graduate of Crestview High School and will attend Ohio State University in the fall, studying animal science. Overmyer is a 2013 graduate of Fremont Ross High School and is currently attending Wilmington College. Women’s Leadership in Agriculture ScholarshipAnderson, Gordon-Coy and O’Reily were honored by The Women’s Leadership in Agriculture Scholarship Program, which was established by the Charlotte R. Schmidlapp Fund, Fifth Third Bank, Trustee. The fund is one of the oldest in the nation and supports academic institutions, social service and charitable organizations providing opportunities “to ennoble, to uplift and to strengthen the lives of young women.” Anderson is a 2015 graduate of Cedarville High School and will be attending Ohio State University in the fall. Gordon-Coy is a 2003 graduate of the University of Akron and is pursuing a master’s in agriculture integrated resource management from Colorado State University. O’Reily is a 2015 graduate of Notre Dame-Cathedral Latin School. Darwin Bryan ScholarshipBauman, Eisenhauer and Klopfenstein are winners of the Darwin Bryan Scholarship. The program commemorates Darwin R. Bryan, whose enthusiastic leadership during his 37 years of service to Ohio Farm Bureau has been an inspiration to rural youth throughout Ohio. Bauman is a 2015 graduate of Ohio Valley Career and Technical Center and will attend Ohio State University to study community and extension education and integrated language arts/English education. Eisenhauer is a graduate of Shelby Senior High School. Klopfenstein is a 2014 graduate of Wayne Trace High School and currently studying agricultural engineering at Ohio State University. Cindy Hollingshead ScholarshipGwirtz, Hand and Jackson are winners of the Cindy Hollingshead Scholarship. The program was established in memory of Ohio Farm Bureau’s 39-year executive secretary who passed away in 2011. Hollingshead was instrumental in the development of Ohio Farm Bureau’s service to its members and a leader in her community. Gwirtz is a 2014 graduate of Shelby High School and is currently attending Ohio State University Agricultural Technical Institute. Hand is a 2015 graduate of Olentangy High School and will attend Michigan State University in the fall. Jackson is a 2015 graduate of Riverside High School. Families and individuals wishing to establish their own life gifts to enhance scholarships and service programs have the opportunity to become involved in the Ohio Farm Bureau Foundation Bequest Society. More information on these and other programs can be found at www.ofbfoundation.org.
Juventus president Andrea Agnelli’s one-year ban for selling tickets to “ultra” fans was lifted on Monday. However, Agnelli’s original fine of 20,000 euros was increased to 100,000 euros.Juventus’ fine was doubled to 600,000 euros and they will have to play one of their home matches with one of its main sections closed.Juventus will have their Curva Sud closed for the home match against Genoa on January 22.The federation’s prosecutor, Giuseppe Pecoraro, had requested a 2 1/2-year suspension for Agnelli and also appealed the original decision.Agnelli allegedly authorized the sale of season passes and other tickets. He acknowledged meeting with Rocco Dominello, an ultra fan linked to the Calabrian ‘ndrangheta crime mob who has since been sentenced to nearly eight years in prison for scalping.But Agnelli said the meetings came only with large numbers of other fans at celebratory occasions, and that the club never intended to engage in illegal activity.The 42-year-old Agnelli has led Juventus, the club his family has owned for nearly a century, since 2010.Anti-mafia prosecutors said the ‘ndrangheta was involved in scalping among Juventus ultra fans for at least 15 years, guaranteeing order in the stadium in exchange for open ticket access.Juventus denied any wrongdoing.Juventus security director Alessandro D’Angelo and ticketing director Stefano Merulla have had their suspensions and fines canceled. D’Angelo was originally banned for 15 months, while Merulla had been handed a one-year suspension.However, former marketing director Francesco Calvo had his appeal rejected and will be banned for one year and will have to pay a 20,000 euro ($24,000) fine.advertisement(Courtesy: AP)
Enlarge ImageImagine looking at a pair of Model 3 headlights coming towards you on a road with nobody behind the wheel. Weird, right? Nick Miotke/Roadshow Tesla’s Autonomy Investor Day was a lot of things. It was a shockingly deep dive into hardware architecture, it was a lesson on training a neural network, and most importantly, it was a look at Tesla’s plans to have a massive fleet of “robotaxis” operating in the US.The idea that we, as a society, could go from having no genuinely Level 5 autonomous cars on the road, let alone available for public use, to having more than a million of them in just a few short years sounds like science fiction, but if Tesla CEO Elon Musk has his way, it won’t be.Musk’s roadmap to having his autonomous taxi fleet is surprisingly direct and well underway. The first big hurdle for any manufacturer attempting something on this scale would be hardware. Tesla gets around that by having installed its self-driving hardware in cars since 2016 — it’s the same hardware that makes Navigate on Autopilot work so well. Tesla Tesla Model 3 Review: Performance trim 9:50 Musk predicts 1 million Tesla robotaxis on the road next… Tesla pulls the wraps off its Model Y crossover SUV Share your voice 9 Photos More From Roadshow The way that a Tesla robotaxi fleet would work, according to Musk, is that Tesla owners could opt into having their car become part of Tesla’s taxi fleet when they weren’t using it. The car would then drive off and do ride-hailing stuff while its owner sat at work or home binge-watching TV.Tesla would charge users for their rides, obviously, and then would take a cut of the car’s earnings off the top. The rest would go to the vehicle owner. In areas where there weren’t enough vehicle owners willing to let their vehicles join the fleet, Tesla would have its own self-managed fleet in place, likely made up of off-lease cars that it’s no longer letting customers buy.All of this would be controlled through the Tesla app, and we get the feeling that, apart from the lack of a driver — and a driver’s penchant for too many air fresheners and awkward conversation — it would feel like a standard ride-hailing service.Musk plans to have Tesla’s full self-driving capability “feature complete” by the end of 2019, with it being ready for unsupervised use by Q2 of 2020 and — this is the big one — 1 million robotaxis on the road testing without passengers by the end of 2020, pending regulatory approval.So what will the economics of this all look like when Musk flips the robotaxi switch? According to his presentation, the yearly income from an autonomous taxi would be around $30,000 gross. Even if you take into account things like wear and tear, and the usage of consumables (which, as we’ve covered before, isn’t much), that’s still a tidy little sum per annum.So, what do you think — will we soon see Tesla’s robotaxis zipping around our city streets? Or is this a case of Musk mucking up his timeline, and robotaxis are still a long way off? Let us know in the comments section. Autonomous Vehicles Electric Cars 2019 Nissan Leaf Plus review: A better EV, but maybe not the best 2 Elon Musk Tesla Self-driving cars Tags Now playing: Watch this: 2020 BMW M340i review: A dash of M makes everything better Comments
Preview • Fujifilm GFX medium-format mirrorless will ship in February for $6,500 $5,499 0 See It 15 Photos Post a comment The GFX100 is substantially larger than the GFX 50S. Lori Grunin/CNET Fujifilm follows up its 50-megapixel mirrorless medium-format GFX 50S and 50R models with the 102MP GFX100, both the least- and most-Fujifilm-like camera the company’s delivered in quite a while. It’s pure Fujifilm in the way that matters: X-T3-like autofocus with fast-for-its-class continuous shooting, 4K video capture, plus the desirable five-axis sensor-shift image stabilization capability that it briefly debuted in last year’s X-H1 but didn’t appear in subsequent cameras. The camera incorporates a medium-format BSI (backside illuminated) sensor, the architecture now used by many of the cameras shipping today. It enables better low-light sensitivity and the performance necessary to shoot 4K video or focus tracking while continuous shooting.Its $10,000 price tag — equivalent to about £7,896 and AU$14,550 — seems roughly what you’d expect given Fujifilm’s other models. Whether or not it’s worth it depends on a lot of unknowns, including the sensor’s dynamic range, image quality and general performance. The camera is slated to ship by the end of June.Just like stepping up from a mainstream camera with an APS-C-size sensor to a larger full-frame model, upping from full-frame to medium format provides benefits like shallower depth-of-field for a given lens aperture and (usually) broader dynamic range because of the larger sensor, even though they cram more pixels into the sensor.Shot with a preproduction version of the GFX100 (and scaled down a lot). Because the raw software was not yet ready, we only had access to JPEGs, so can’t really make any determinations about the sensor or image quality. Lori Grunin/CNET In the short time I got to use it, the autofocus seemed quite snappy. But it’s impossible to draw any conclusions from the handful of JPEG images I shot except that they’re big and sharp with pretty colors — all completely unsurpising.Highlights include:Up to DCI 4K/30p video (it uses the full width of the sensor), with 4:2:0 8-bit internal or 4:2:2 10-bit external with most video capabilities same as the X-T3.5fps continuous shooting with focus tracking at full resolution and 14-bit color (standard is 16 bits) using Fujifilm’s X-Processor 4, the same quad-core processor that’s in the X-T3. While 5fps may not sound like much, it’s practically zippy compared to other medium-format models.On-sensor phase-detection autofocus (about 3.8 million PD sensors) covering almost 100% of the frame plus the 425-point contrast autofocus as the GFX 50S. Focus sensitivity as low as -2 EV.Native sensitivity of ISO 100 – ISO 12800, with expansion down to ISO 50 and up to ISO 102400, similar to the GFX 50S.The same 3.7MP OLED viewfinder as the GFX 50S.Dust and weather resistance.Dual UHS-II SD card slots, mic and headphone jacks and a USB-C connection.The GFX100 veers from Fujifilm tradition with its design — in a good way. It sports no retro camera dials and has built-in vertical grip that holds two batteries. Physical dials are more a curse than a blessing for shooting video, at the least because you want different presets or defaults for stills and video and the physical dials override those. And mirrorless cameras’ battery life is bad enough in general, with the sensor stabilizer draining them even more, that you want to carry multiples. The GFX100’s rated life is 800 shots for a pair. In fact, the body design bears little resemblance to the earlier GFX models. All told, the GFX100 is roughly the size and weight of the full-frame Nikon D5, though you can remove the viewfinder if you choose. Not only is the sensor large compared to a full-frame — it’s 43.8×32.8 mm compared to 36x24mm — but it’s floating in the stabilization mechanism, so the whole unit takes up quite a bit of space. See it Fujifilm GFX100 medium-format mirrorless dispenses with the dials Fujifilm GFX 50S $5,499 But Fujifilm couldn’t let go of its shutter speed and ISO dials entirely. The top display cycles through several readouts, one of which presents you with virtual versions of the two dials. I found them a little glitchy to use — when rotating I’d end up on the wrong settings because of the way the display updated, though they were preproduction units so that may change. But they also seemed unnecessary.A drive mode button and mode switch sits on the left shoulder, while the back controls are pretty typical Fujifilm. It incorporates the multiangle tilting touch display as the X-T3. While it’s nice to have the capability, I’ve always found the implementation a little cumbersome to use quickly and precisely. It also has the duplicate setting display you’d find on a pro model like the D5 or the Canon EOS-1D X Mark II, and both the horizontal and vertical grips are comfortable enough to handle the weight of the body and the lens, much like the GFX 50 series. The off-center viewfinder means it feels different shooting horizontally than it does vertically, which may bother some people.The GFX models have always felt like the most mainstream of the medium-format cameras — even the “casual” Hasselblad X1D felt like it belonged in the studio more than the street — and the capabilities added in the GFX100 make it seem like a perfect step up from a full-frame model — DSLR or mirrorless — for event photography. I hope Fujifilm decides to bring the speed and versatility down to a lower resolution like 50MP, and therefore a lower price.Updated May 28, 2019: Corrected the misstatement about this being the first to use a 100-megapixel BSI sensor. Share your voice Walmart Mentioned Above Fujifilm GFX 50S $6,326 Amazon CNET may get a commission from retail offers. Cameras See It Tags Canon Fujifilm Nikon
Kashish ChopraPR HandoutFashionista Kashish Chopra is a Mumbai and Delhi based model, who has endorsed several brands. Now, she is all set to make her acting debut with a few Gujrati and Tamil movies, which are slated for release soon.Kashish Chopra says a sacrifice to be real must cost, hurt and empty ourselves. But we should turn out to be a hero of our own life. This never-ending urge to fight back and stand tall has given her the lifestyle she dreamed of being a Superstar. Kashish started Modelling since after her graduation and the dedication kept her going till she became a renowned person in the Bollywood Industry.The love and desire for fashion and being a shopaholic keep her looking flawless every time you see her because she dresses neat and crisp, playing with the right colours and looking just alluring always. She does blogging as a hobby, a part-time time thing, which brings immense joy to her while impersonating the people about style, fitness and lifestyle said by kashish ! Kashish ChopraPR HandoutKashish Chopra is a Mumbai and Delhi based model who has collaborated with notable brands like Forever 21, Zara, Charles and Keith, Call it Spring, H&M, Woodland, ultimate nutrition, Puma, Nike, Pixi, Zivami and many more. She is also looked upon as a fitness model for Healthvit and many international brands.Kashish Chopra is quite active on social media andis an influencer. She is a fitness and fashion enthusiast. She has more than 500,000 plus followers on Instagram and more than 10,000 fans on the Facebook account.The fashionista has a heart for acting and has signed few Gujarati and Tamil which are about to release & recently signed few Punjabi songs. She says she’s very lucky to be in this Industry as this helps us to connect with astounding people and brands across the globe. It helps her to learn everything each passing day.
In one of the most interesting developments in tech for some time (and that’s saying something), Bloomberg are reporting that Microsoft has acquired GitHub. Spokespeople from Microsoft and GitHub declined to comment when asked by Bloomberg, but the deal could be announced later today. With 24 million users on the platform, this move could well have an impact across the software world. However, while it may seem surprising, it isn’t perhaps quite as shocking as it immediately appears. Microsoft has embraced open source in the last few years; the company is one of the top contributors to the site, according to The Verge. When were rumors of Microsoft’s intention to buy GitHub first reported? Reports of Microsoft’s intention to acquire GitHub were first made in Business Insider just a few days ago, at the beginning of June 2018. According to the website, sources ‘close to both companies’ said that serious talks have been happening for the past few months. Informal discussions on the issue have taken place over the last few years – it’s only now that they have become more serious. With GitHub’s CEO Chris Wanstrath set to leave in August, it makes sense for Microsoft to take the opportunity to make a move to acquire the company now. Why would Microsoft want to acquire GitHub? Microsoft has been playing catch up with the open source revolution. It’s attitude towards open source has changed significantly in recent years. It has open sourced a growing number of its tools, including PowerShell, Visual Studio Code and .NET. Back in 2001, former Microsoft CEO Steve Ballmer called Linux a “cancer” (he did later retract his statement). Today, under Satya Nadella, it’s a completely different story. For that reason, the acquisition of GitHub represents an important step in the evolution of Microsoft’s relationship to the open source world. There are questions around how much Microsoft is really committed to open source. To cynics, embracing open source is as much about business than values. Billion dollar acquisitions don’t exactly scream ‘free and open software’. However, it is still early days. How the acquisition unfolds, how it will be received by the developer community will be interesting. Whatever you think of the Microsoft’s move, GitHub isn’t exactly thriving from a business perspective; GitHub lost $66 million in three quarters in 2016. Read next 10 years of GitHub Microsoft releases Windows 10 Insider build 17682! Epicor partners with Microsoft Azure to adopt Cloud ERP