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Targeting fat-tissue hormone may lead to type 2 diabetes treatment

By on March 1, 2021

first_imgA new study by researchers from Harvard T.H. Chan School of Public Health and colleagues describes the pre-clinical development of a therapeutic that could potentially be used to treat type 2 diabetes, fatty liver disease, and other metabolic diseases. The researchers developed an antibody that improves glucose regulation and reduces fatty liver in obese mice by targeting a hormone in adipose (fat) tissue called aP2 (also known as FABP4).The study was published online December 23, 2015 in Science Translational Medicine.“The importance of this study is two-fold: first, demonstrating the importance of aP2 as a critical hormone in abnormal glucose metabolism, and secondly, showing that aP2 can be effectively targeted to treat diabetes and potentially other immunometabolic diseases,” said Gökhan S. Hotamisligil, J.S. Simmons Professor of Genetics and Metabolism and chair of the Department of Genetics and Complex Diseases and the Sabri Ülker Center at Harvard Chan School.The work is the product of a collaboration on immunometabolism between the biopharmaceutical company UCB and a team of researchers led by Hotamisligil and lead author M. Furkan Burak, a former Hotamisligil lab member and currently a resident in internal medicine at Mount Auburn Hospital, Cambridge, Mass. This partnership successfully twins UCB’s world-class expertise in monoclonal antibody discovery with Hotamisligil’s insight and experience in aP2 biology. Read Full Storylast_img read more

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Roglic retains Tour de France lead as Kwiatkowski wins stage 18

By on October 19, 2020

first_imgPrimoz Roglic retained his lead on compatriot Tadej Pogacar atop the Tour de France standings after stage 18 as British outfit Ineos claimed a one-two finish on Thursday.Bedevilled by problems that saw them withdraw their captain Egan Bernal on Wednesday, team-mate Michal Kwiatkowski won the stage as Richard Carapaz took the King of the Mountains jersey with the pair crossing the finish line three minutes ahead of the elite pack.”I had the best legs ever, the way we rode together with Richard was just incredible,” said Ineos’s Polish rider who is a former world champion. Topics : “When Egan left the race he was very sad but wished us well, and now we have this wonderful day,” he said.”That’s the Tour de France,” he beamed.Giro d’Italia champion Carapaz has been a revelation over the three Alpine stages that culminated with the Ineos-led escape here as the Ecuadorian has relentlessly attacked, picking up climb points to take the polka dot jersey.center_img Beaming with joy Carapaz was drafted into the race at the last minute as Geraint Thomas was farmed out to the Giro, but he fell on stage one in the deluge in Nice and is only finding his full form now.Carapaz and Kwiatkowski were clearly brimming with joy over the fruits of their partnership, which will have brought some relief for Ineos team principal Dave Brailsford, who had to pull out his protégé Bernal to protect him.”Adapting quickly to change is one of the main keys of success,” Brailsford said ahead of the Tour in Nice.”We worked so hard since we changed our objectives,” Kwiatkowski said fighting back tears.In the race for the overall standings only Saturday’s individual time trial presents a chance for the second-placed Pogacar to stage a coup.Roglic leads Pogacar by 57 seconds with Friday’s stage 19 and the culminating run up the Champs-Elysees on Sunday both set to be decided in a mass bunch sprint.Roglic once again looked at ease during the run over three major mountains.”I managed to relax, everything went fine, another good day for us,” Roglic said, as he grows into the role of leader which seemed to weigh on him when he took the lead in the first week.”I’ve been thinking about the time trial, I’ll make the decision how I play it on the day,” he said looking to Saturday’s decider.Stage 17 solo winner Miguel Angel Lopez of Colombia is still third 1min 27sec off the lead but is less of a time-trailer than his rivals.Often unlucky Australian Richie Porte survived a puncture atop the final plateau section where the peloton had to negotiate a gravel surface.Spain’s Mikel Landa rounds out the top five after Briton Adam Yates lost some time over the final climb.last_img read more

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Smith races to first Modified win at Oshkosh

By on September 23, 2020

first_imgBy Dave PanskeOSHKOSH, Wis. (June 13) – T.J. Smith will argue any inference of full moon racing couple with a Friday the 13th after winning his career first Automotive Supply Company IMCA Modified feature at Oshkosh SpeedZone Raceway.Smith grabbed the lead at the start with Jim Rhode Ed Lemay, Eric Arneson, Jeremy Christians and Travis Spaulding close behind. Several early cautions kept the field bunched but Smith was able to maintain to lead through a green flag run from laps four to 10.Christains moved into the runner-up spot on lap six with Mike Wedelstadt and Eddie Muenter moving into the top five by lap seven. With the field right behind for the restart, Smith again set the pace and opened a car length lead over Christians as Muenster, Rhode and Wedelstadt moved up to challenge for second.A final caution on lap 17 set up a three-lap dash, with Smith drawing on his past experience to just run his race and drove off with his first career division feature win. Muenster wrestled the second place finish from Christians on the final lap with point leader Sean Jerovetz making a late-race run to fourth over Wedelstadt and Rhode. Other feature winners were John Heinz in his second straight Total Power Sales IMCA Stock Car feature while Steve Schneider picked up his third Karl Chevrolet Northern SportMod victory on the season.last_img read more

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Ohio Farm Bureau Federation Foundation scholarships

By on December 18, 2019

first_imgShare Facebook Twitter Google + LinkedIn Pinterest Twelve young Ohioans have been named recipients of $1,500 college scholarships from the Ohio Farm Bureau Federation Foundation. Supported by the Ohio Farm Bureau Federation, the foundation annually recognizes Ohio students for their academic effort, engagement in their communities and career interests that link agriculture to community service, education or scientific research.Scholarship winners for 2015 are Brooke Anderson of Xenia, Emily Bauman of Otway, Kristen Eisenhauer of Shiloh, Amy Jo Frost of Bloomingburg, Nicki Gordon-Coy of Carrollton, Brianna Gwirtz of Shelby, Rachel Hand of Lewis Center, Ella Grace Jackson of De Graff, Matthew Klopfenstein of Haviland, Abigale Motter of Mansfield, Amanda O’Reily of Middlefield and Lindsay Overmyer of Fremont. Ohio Farm Bureau Foundation Scholar AwardFrost, Motter and Overmyer are recipients of the Ohio Farm Bureau Foundation Scholar Award, which recognizes students for academic effort, community service and career interests that use agriculture to enhance the partnership between farmers and consumers. Frost is a 2009 graduate of Miami Trace High School, 2014 graduate of Ohio State University and is currently pursuing a master’s degree in agricultural and extension education. Motter is a 2015 graduate of Crestview High School and will attend Ohio State University in the fall, studying animal science. Overmyer is a 2013 graduate of Fremont Ross High School and is currently attending Wilmington College. Women’s Leadership in Agriculture ScholarshipAnderson, Gordon-Coy and O’Reily were honored by The Women’s Leadership in Agriculture Scholarship Program, which was established by the Charlotte R. Schmidlapp Fund, Fifth Third Bank, Trustee. The fund is one of the oldest in the nation and supports academic institutions, social service and charitable organizations providing opportunities “to ennoble, to uplift and to strengthen the lives of young women.” Anderson is a 2015 graduate of Cedarville High School and will be attending Ohio State University in the fall. Gordon-Coy is a 2003 graduate of the University of Akron and is pursuing a master’s in agriculture integrated resource management from Colorado State University. O’Reily is a 2015 graduate of Notre Dame-Cathedral Latin School. Darwin Bryan ScholarshipBauman, Eisenhauer and Klopfenstein are winners of the Darwin Bryan Scholarship. The program commemorates Darwin R. Bryan, whose enthusiastic leadership during his 37 years of service to Ohio Farm Bureau has been an inspiration to rural youth throughout Ohio. Bauman is a 2015 graduate of Ohio Valley Career and Technical Center and will attend Ohio State University to study community and extension education and integrated language arts/English education. Eisenhauer is a graduate of Shelby Senior High School. Klopfenstein is a 2014 graduate of Wayne Trace High School and currently studying agricultural engineering at Ohio State University. Cindy Hollingshead ScholarshipGwirtz, Hand and Jackson are winners of the Cindy Hollingshead Scholarship. The program was established in memory of Ohio Farm Bureau’s 39-year executive secretary who passed away in 2011. Hollingshead was instrumental in the development of Ohio Farm Bureau’s service to its members and a leader in her community. Gwirtz is a 2014 graduate of Shelby High School and is currently attending Ohio State University Agricultural Technical Institute. Hand is a 2015 graduate of Olentangy High School and will attend Michigan State University in the fall. Jackson is a 2015 graduate of Riverside High School. Families and individuals wishing to establish their own life gifts to enhance scholarships and service programs have the opportunity to become involved in the Ohio Farm Bureau Foundation Bequest Society. More information on these and other programs can be found at www.ofbfoundation.org.last_img read more

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Juventus president Andrea Agnelli ban lifted for selling tickets to ultra fans

By on November 18, 2019

first_imgJuventus president Andrea Agnelli’s one-year ban for selling tickets to “ultra” fans was lifted on Monday. However, Agnelli’s original fine of 20,000 euros was increased to 100,000 euros.Juventus’ fine was doubled to 600,000 euros and they will have to play one of their home matches with one of its main sections closed.Juventus will have their Curva Sud closed for the home match against Genoa on January 22.The federation’s prosecutor, Giuseppe Pecoraro, had requested a 2 1/2-year suspension for Agnelli and also appealed the original decision.Agnelli allegedly authorized the sale of season passes and other tickets. He acknowledged meeting with Rocco Dominello, an ultra fan linked to the Calabrian ‘ndrangheta crime mob who has since been sentenced to nearly eight years in prison for scalping.But Agnelli said the meetings came only with large numbers of other fans at celebratory occasions, and that the club never intended to engage in illegal activity.The 42-year-old Agnelli has led Juventus, the club his family has owned for nearly a century, since 2010.Anti-mafia prosecutors said the ‘ndrangheta was involved in scalping among Juventus ultra fans for at least 15 years, guaranteeing order in the stadium in exchange for open ticket access.Juventus denied any wrongdoing.Juventus security director Alessandro D’Angelo and ticketing director Stefano Merulla have had their suspensions and fines canceled. D’Angelo was originally banned for 15 months, while Merulla had been handed a one-year suspension.However, former marketing director Francesco Calvo had his appeal rejected and will be banned for one year and will have to pay a 20,000 euro ($24,000) fine.advertisement(Courtesy: AP)last_img read more

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